Each boss only has 2,000HP, making them susceptible to concentrated fire. Zomboss hover above the battlefield as giant targets. Keep in mind that in Boss Mode, you ARE NOT invincible - quite the opposite in fact, as both Crazy Dave and Dr.
You will have to grab them, with each worth 25 of that resource, to effectively deploy your resources and troops. When playing in this mode, Brainz and Sundrops will fall on the screen. The biggest challenge in Boss Mode is managing resources.